Granulosis rubra nasi is a rare condition characterised by hyperhidrosis of the nose. Granulosis Rubra Nasi (GRN) is a rare disorder of the eccrine glands. It is clinically characterized by hyperhidrosis of the central part of the face. Granulosis rubra nasi is a rare familial disease of children, occurring on the nose, cheeks, and chin, characterized by diffuse redness, persistent excessive.

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We hope this case report will prompt other authors to use and document the response of tacrolimus in various stages of GRN. Rosacea can be differentiated by accentuation of the erythema by vasomotor instability, which is not a feature of GRN.

GRN is a rare disorder. By using this site, you agree to the Terms of Use and Privacy Policy. New lesions kept appearing.

Granulosis rubra nasi

Nnasi usually start in early childhood in patients aged 6 months to 10 yearsbut can arise at any age in childhood and occasionally in adults. Granulosis rubra nasi is a rare nwsi disease of children, occurring on the nose, cheeks, and chin, characterized by diffuse redness, persistent excessive sweatingand small dark red papules that disappear on diascopic pressure.

Other differential diagnosis include acne vulgaris, lupus pernio, and lupus erythematosus. There was history of summer aggravation; however, she was never lesions free, even during winter months. Footnotes Source of Support: This is a chronic, benign condition of unknown etiology [ 24 ].


He was otherwise nais and there was no relevant family history. Other differential diagnoses include acne vulgaris, lupus pernio, lupus erythematosus, lupus vulgaris, leishmaniasis, actinic keratosis or skin cancer, miliaria crystallina, and hidrocystoma [ 2410 ].

In next 4—5 years, papular lesions stopped appearing. The histopathology report showed epidermal hyperplasia with spongiosis. Conditions of the skin appendages Condition of the skin appendages stubs. Lupus pernio or chilblain lupus presents with dusky papules and plaques on the nose, toes, and fingers.

In rosacea there is erythema of the cheeks and nose along with telangiectasias but no hyperhidrosis of the central part of the face.

Small beads of sweat can be seen at the tip of the nose. Some authors have suggested a defect in vasomotor and secretory functions of the nose. This website is non-profit and holds the images for educational purposes only.

We here report a case of GRN having lesions persisting in adulthood. Website author — Dr Tim Cunliffe read more.

View at Google Scholar E. The rest of the physical examination was normal. However, erythema over the central face was persisting. The diagnosis is largely clinical. Support Center Support Center.

Pilosebaceous units are normal and masi heterotopic apocrine glands are found[ 3 ] This disease usually remits after puberty, unlike the primary forms of localized hyperhidrosis but sometimes may continue into adulthood. Miliaria crystallina presents with vesicles mainly over the areas occluded by clothes.

It used to get worse in summer and was associated with localized hyperhidrosis. Open in a separate window. We are not in granluosis position to comment on the response of tacrolimus in earlier stages of disease process, when hyperhidrosis is prominent as we got the patient in a very late stage.


In the English literature Maschkillesson and Neradow have recorded cases and the disease was not thought to be rare.

Granulosis rubra nasi: a rare condition treated successfully with topical tacrolimus

It has a chronic course and resolves at granulosos without any sequelae. Koilonychia Nail clubbing behavior: This article has been cited by other articles in PMC.

The infundibular and sebaceous ducts are plugged with stratum corneum and villous hair follicles. Histopathology from the vesicle revealed mononuclear cell infiltration in the upper dermis along with dilatation of superficial capillaries and lymphatics Figure 2 A,B. After having the discussion with patient, decision was made to continue Tacrolimus.

Any image downloaded must only be used for teaching gtanulosis and not for commercial use. Cynthia SargunamJayakar Thomasand N. No preventive measures or complications are reported and the disease has an excellent prognosis with self resolution at puberty in most cases. Histology shows dilation of dermal blood vessels and lymphatics with perivascular lymphocytic infiltration and dilation of sweat ducts.