Follicular mucinosis is a term that encompasses three related entities. Alopecia mucinosa, Urticaria-like follicular mucinosis, and cutaneous lymphoma related. On hair-bearing skin (e.g. scalp), overlying alopecia is notable, hence the term “ alopecia mucinosa” (see Figure 5). Plaques are often composed of densely. Alopecia mucinosa is a skin disorder that generally presents, but not exclusively, as erythematous plaques or flat patches without hair primarily on the scalp.

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Angiolymphoid hyperplasia with follicular mucinosis. This triggers an inflammatory response, and affects the follicles ability to produce hair. The biopsy showed a moderately dense superficial and mid perivascular infiltrate of lymphocytes with occasional eosinophils without any granulomas in the sections. Subsequently the lesion was seen to have completely cleared at follow up at the end of 1 and 2 years. The following options have been anecdotally reported to be effective; selection is based on individual patient tolerance and comorbidities, and on the comfort level of the prescribing physician.

It is possible that these activated T lymphocytes may cause mucin accumulation in the affected follicles, and it is conceivable that follicular mucinosis may occur in lesions of leprosy without a,opecia. Follicular mucinosis as the only histological finding without granulomas has been recently aloopecia in children with suspected alppecia who had complete clearing of the lesions with standard multi drug therapy MDT for leprosy.

With loss of the follicle, alopecia may be evident clinically.

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If you have any concerns with your skin or its treatment, see a dermatologist for advice. Received May; Accepted Aug. Secondary causes of alopecia mucinosa such as mycosis fungoides may mudinosa be diagnosed for some years, necessitating careful follow-up and biopsy. Beau’s lines Yellow nail syndrome Leukonychia Azure lunula shape: A clinical diagnosis of leprosy was considered and a 3 mm punch biopsy sample revealed features of follicular mucinosis with most follicles in the sections showing spaces between keratinocytes containing wisps of bluish mucin.


Additional markers for the type 1 reactional states in borderline leprosy. She completed 6 months of MDT in Decemberat which a,opecia the lesion had cleared completely with regrowth of all hair [ Figure 1b ].

The etiology is not known. Follicular Mucinosis and Alopecia Mucinosa. The objective of this paper is to draw attention to an unusual finding, that is, rapid and complete response of Alopecia mucinosa to antileprosy treatment with no subsequent relapse over fairly long periods of posttreatment observation.

Abstract Three cases with single lesion of Alopecia mucinosa follicular mucinosis were treated with antileprosy treatment and showed rapid and complete resolution of the lesions with no recurrence on extended follow-up. Retrieved from ” https: Alopecia mucinosa most commonly affects face, neck and scalp, but any part of the body may be affected. All our cases presented with single lesions which demonstrated hypoesthesia.

Follicular Mucinosis (Alopecia Mucinosa)

The treatment was, however, started a month later as she was in her village for the summer holidays. Alopecia mucinosa, also known as follicular mucinosis, describes the appearance of mucin around hair follicles as seen under the microscope. Secondary alopecia mucinosa, which many now consider to be mycosis fungoides, presents in older individuals, with or without other features of mycosis fungoides.

Which of the following best describes your experience with hand-foot-and-mouth disease? Follicular infundibulum keratinocytes and outer root sheath are separated by pools of mucin Mixed infiltrate of lymphocytes, histiocytes and conspicuous eosinophils Marked follicular dilation with cyst formation and perifollicular scarring Alopeciq the dermis and and affected epithelium are typically infiltrated by lymphocytes, histiocytes and eosinophils In cases associated with lymphoma, atypical lymphocytes, alopscia lymphocytes, large transformed cells and mitotic figures may be seen.

Follicular mucinosis is a histological reaction pattern wherein variable amounts of epidermally derived mucin accumulate within follicular infundibula and the outer root sheath epithelium.

Clinical, histological and immunological remission with minocycline. Follicular mucinosis presenting as acute dermatitis with response to dapsone. Footnotes Source of Support: A month later the patch had enlarged minimally, the surface was dry and showed follicular prominences, however, no erythema was alopeecia [ Figure 1a ]. The authors suggest that in regions endemic for leprosy, such as India, single lesion Alopecia mucinosa on the face in children and young adults should be given antileprosy treatment.


Based on clinical suspicion both were started on multi drug therapy MDT for leprosy with complete resolution of the lesions. Vanessa Ngan, Staff Writer, Lymphocytes were seen infiltrating the follicular epithelium but no atypical lymphocytes were seen. Minocycline mg orally, twice daily; response noted within 6 months; begin to taper slowly over months after lesions have cleared. Nil Mucimosa of Interest: This condition of the skin appendages article is a stub. A year-old boy presented in Septemberwith a hypopigmented and hypoaesthetic shiny patch apopecia the left cheek of few months duration.

X40, B X mucinos Follicular mucinosis responding to dapsone. Three cases with single lesion of Alopecia mucinosa follicular mucinosis were treated with antileprosy treatment and showed rapid and complete resolution of the lesions with no recurrence on extended follow-up.

Case Reports Case 1 A year-old boy presented in Septemberwith a mhcinosa and hypoaesthetic shiny patch on the left cheek of few months duration. Click here for information on linking to our website or using our content or images. National Center for Biotechnology InformationU. And are there other choices? Support Center Support Center.

Several lymphocytes were seen infiltrating the affected follicular infundibula. Primary or alopwcia Alopecia mucinosa was first described in by Pinkus. Skin inflammatory nontumor Alopecia Alopecia mucinosa Author: Consider if patient is intolerant or unresponsive to first-line agents. Familial reticuloendotheliosis with eosinophilia and follicular mucinosis.